There are no controlled trials of high dose corticosteroids in the treatment of multiple sclerosis relapses during pregnancy. Animal studies have demonstrated reduction in fetal growth and compromised central nervous system development with large doses of prenatal corticosteroid. In women with other steroid dependent diseases, fetal adrenal suppression, and hypoglycaemia (usually short term) cleft lip, prematurity and stillbirth have been reported, although again there are limited data in pregnancy.16,32.
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